Two Palestinian suspects were captured, Israeli police spokesman Micky Rosenfeld said, with one shot and the second arrested at the upscale Sarona Market.
Surveillance footage from a cafe near the shooting scene showed chaos as panicked customers scrambled, knocking over chairs and tables as they rushed to escape. People crawled across the floor and others carried children in their arms.
Amir Ohana, a member of the Israeli Parliament who was at Sarona Market, told CNN that people were enjoying a serene night when violence erupted.
Police survey the scene of a terror attack in Tel Aviv.
"People were having coffee," he said. "I saw a birthday cake on one of the tables. And then you see the chairs upside down and glass shattered and blood all over."
The four fatalities were Israeli, Rosenfeld said. At least five other people were wounded in the carnage, said Dr. Gil Fire, deputy director of Ichilov Hospital. An injured suspect also was treated.
Information about a motive wasn't immediately available. No intelligence suggested an attack was imminent, Rosenfeld said. No group has claimed responsibility.
The attackers were dressed as Hasidic Jews, said a law enforcement source briefed by Israeli officials.
'Attack the attackers'
Prime Minister Benjamin Netanyahu called the killings "a savage crime, murder in the heart of Tel Aviv."
"We will take the necessary steps to attack the attackers and defend those who need to be defended," he said.
Police officers shot one of the suspects. The other surrendered, Rosenfeld said.
Sarona Market is a mixed-use development with a food hall, upscale retail, playgrounds, green space and residences on a central highway. The market, which opened last year, is across the street from Israel's Defense Ministry and main army headquarters.
A press release from the opening of the complex described it as an 8,700-square-meter complex with 91 stalls, shops and restaurants selling food from around the globe.
The Jerusalem Post reported in April that Tel Aviv police wanted to close the market because of "security flaws and safety shortcomings that present a risk to the public's safety."
But a spokesman for Gindi Holding, which built the market, told The Post the complex would not be closed and that violations only involved tables and chairs blocking entrances and exits and the way security guards were inspecting visitors at the door.
Violence in Tel Aviv
U.S. State Department deputy spokesman Mark Toner issued a statement condemning "today's horrific terrorist attack in Tel Aviv in the strongest possible terms."
"These cowardly attacks against innocent civilians can never be justified," he said. "We are in touch with Israeli authorities to express our support and concern."
Israeli authorities said terrorists attacked a popular gathering spot in Tel Aviv.
Israeli Ambassador to the United Nations Danny Danon called on the Security Council to condemn the attack.
"Today's heinous attack sadly proves that when the international community refuses to condemn terror against Israelis, the next attack is only a matter of time," he said in a statement. "Terror in Tel Aviv must be treated the same as terror in Paris or Istanbul."
Rosenfeld said knife attacks have been more common lately, with the last shooting in Tel Aviv occurring months ago.
CNN's Michael Schwartz, Phil Black and Oren Liebermann reported from Jerusalem. CNN's Ralph Ellis, Emanuella Grinberg and Steve Visser reported from Atlanta.
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