The case was detailed in a report by the U.S. Department of Defense on Thursday. Centers for Disease Control and Prevention Director Dr. Tom Frieden talked about the case at the National Press Club in Washington.
The woman went to a clinic in Pennsylvania, and a sample was forwarded to Walter Reed National Military Medical Center. Walter Reed found the bacteria in her urine. There is no indication of how the bacteria got into the woman's system. She had not traveled outside the United States within the past five months.
The woman was treated and released and has no other medical problems related to the bacteria that we know of, according to Dr. Alex Kallen, a medical officer with the CDC.
The CDC said it is looking for other potential cases in the health care facility the patient visited.
These two cases are what the CDC characterized as a "warning sign, more than a catastrophe," according to Kallen.
The concern is that traits of this rare mutant Colistin-resistent E. coli could jump to other bacteria that respond only to Colistin, creating a potentially unstoppable superbug.
One report suggests that antibiotic-resistant infections can result in the deaths of half the patients who become infected.
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Frieden warned that although this is the first case in the United States, we should expect to see more such superbugs in the near future. Frieden, who often warns doctors against overuse of antibiotics, urged scientists to develop new drugs quickly.
"The medicine cabinet is empty for some patients," Frieden said. "It is the end of the road unless we act urgently."
CNN's Elizabeth Cohen contributed to this report.
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