. The study of curcumin degradation has been carried out by optimizing the effect of pH and solvents using the UV-Vis spectrophotometric method. The stability of curcumin decreased as pH increased. Curcumin was degraded rapidly in alkaline solutions. Curcumin has different maximum wavelengths in the different solvents. The UV spectrum of curcumin shifted as the pH increased. The UV spectra of curcumin shifted towards a smaller wavelength in alkaline solution. The shift in the UV spectra was due to curcumin degradation in an alkaline solution. In addition, Density functional Theory (DFT) calculation was carried out to simulate the curcumin and its degradation product ground states and excited states. The absorption spectra calculated using the TDDFT method showed that the max imum wavelength of curcumin and its degradation products agreed with the experimental data. INTRODUCTION Curcumin has been widely reported for its pharmacological activities such as anti-inflammatory, antibacterial, and antiviral, as well as its therapeutic potential for cancer and Alzheimer's disease [1]. However, it was reported that curcumin has poor bioavailability due to its hydrophobic properties [2]. Curcumin was not found in tissues after oral administration for 29 days at a dose of 440-2200 mg/day [3]. According to [4], there was a possibility that the pharmacological effect of curcumin came from its degradation product which has higher water solubility. Several studies on curcumin d
Download PDF: https://tirna.eu.org/hOwEVl
